R3 Extreme - Technical Specifications


R3 Extreme is a dietary supplement designed to neutralize compounds that compromise the exercise-recovery process, supply factors that decrease the time needed for recovery, and protect newly growing tissues in the body by enhancing the functions of the immune system.

Through halting the undesired catabolic effects of cortisol, the body’s state of recovery is enhanced and able to constantly progress. When providing the essential building blocks needed for growth and reducing the effects of delayed muscle soreness, the recovery process can occur much more quickly. Additionally, when the functions of the immune system are magnified, the amount of growth that can occur is unlimited while in the anabolic state associated with R3 Extreme supplementation.

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Glutamine-AKG


Key Action:
Glutamine-AKG is essential in the recovery process from any type of trauma or exercise-induced tissue damage. It is anti-catabolic, aids immune function as a precursor for rapidly dividing immune cells, and increases glycogen storage in skeletal muscle. It increases ATP synthesis and enhances the absorption of compounds to which it is bound.

Physiological Mechanism:
Glutamine aids in the trauma recovery process as an amino acid, participating in protein synthesis, particularly of structural proteins that repair skeletal muscle. Glutamine also increases intramuscular glycogen and prevents glycogen breakdown.

Colostrum


Key Action:
Colostrum increases lean muscle mass while breaking down fat, and is a source of vitamins and essential nutrients as well as TGF-B proteins.

Physiological Mechanism:
Peptide hormones found in colostrum act as signaling molecules to increase protein synthesis and increase muscle mass via the activation of specific transcription factors. During this process, ATP is needed for energy to fuel these anabolic processes. ATP is derived from fat cells via the formation of acetyl-CoA, which results in a decrease in body fat with a concomitant increase in lean body mass.

Arabinogalactan


Key Action:
Arabinogalactan is a proteoglycan with immunomodulatory activity; it is also anti-catabolic and probiotic.

Physiological Mechanism:
Arabinogalactan is a highly branched polysaccharide that enhances the activity of beneficial digestive bacteria, decreases ammonia excretion, and improves nitrogen retention. Most importantly, arabinogalactan has the capability to enhance the activity of natural-killer T cells and promotes a more responsive immune system, especially in cases in which the immune system is compromised, such as in disease.

Kre-Celazine


Key Action:
Kre-Celazine is a potent anti-inflammatory compound that helps to maintain the structure of cellular phospholipid membranes. It increases ATP storage and equalizes pH levels in various systems of the body.

Physiological Mechanism:
As an esterfied compound, Kre-Celazine donates lipids to cell membranes to enhance their structure. It also inhibits arachidonic acid as well as many other fatty acids that contribute to inflammation and decreases COX-2 enzyme activity. Kre-Celazine increases the body's ability to store high levels of ATP by supplying a creatine phosphate precursor. This compound is also buffered, which resists changes in acidity and alkalinity to maintain stable pH levels.

N-acetylcysteine


Key Action:
N-acetylcysteine (NAC) is a precursor of glutathione, which is essential for liver function. It is also a potent antioxidant.

Physiological Mechanism:
NAC is the primary precursor of glutathione (GSH), which is an extremely potent antioxidant and scavenger of free radicals that prevents damage to cells and DNA. NAC traps direct-acting mutagens and blocks mutagenic metabolites to prevent DNA damage. NAC also protects certain nuclear enzymes that enhance DNA repair. It increases cellular ATP levels and increases the protein complexes used in oxidative phosphorylation. Additionally, NAC has been shown to have anti-inflammatory activity by inhibiting COX-2 protein and cytokine production.

Beta-1,3-Glucan


Key Action:
Beta-1,3-Glucan is a polysaccharide with anti-bacterial and anti-fungal properties. It aids in wound healing and has been used in anti-cancer therapy and radiation treatment.

Physiological Mechanism:
Beta-1,3-Glucan enhances the functions of macrophages, neutrophils, and natural killer T cells to recognize and destroy foreign invaders. It also enables those cells to recognize cancer cells as "non-self" and hence destroy them.

Curcumin


Key Action:
Curcumin has antioxidant, anti-tumor, anti-inflammatory, and anti-arthritic properties. It prevents both oxidative DNA damage and lipid peroxidation.

Physiological Mechanism:
Curcumin prevents inflammation and subsequent oxidative stress by interfering with nuclear factor kappa-B (NF-kB). The inhibition of NF-kB prevents the cell from producing an immune response, thereby blocking inflammation.

Phosphatidylserine


Key Action:
Phosphatidylserine regulates cortisol synthesis and maintains cortisol at healthy levels. It is also anti-catabolic.

Physiological Mechanism:
Both psychological and physical stresses cause an increase in cortisol levels. Cortisol is a catabolic hormone that increases the storage of fat cells and facilitates the breakdown of skeletal muscle proteins as a means to obtain energy. Phosphatidylserine (PtdSer) maintains cortisol levels within a healthy range and blocks cortisol catabolism.